Matériaux et Biomatériaux innovants

 

Génétique et Epigénétique des Champignons

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L'équipe GEC fait partie du Laboratoire Interdisciplinaire des Energies de Demain (LIED), UMR 8236

Responsable de l'équipe:
Professeur Philippe Silar

Tel: (33) 1 57 27 84 72

E-mail:philippe.silar@univ-paris-diderot.fr

 

 

SENESCENCE

- Senescence has not yet yielded all its secrets! Especially, the nature of the cytoplasmic determinant is still unkown. It leads to cell death and is accompanied by a "destabilisation of the mitochondrial DNA", a symptom that is also found in many ageing organisms. Numerous genes influence the Determinant of Senescence, especially those involved in cytosolic protein synthesis. We postulate that destabilisation of the mitochondrial is triggered through modifications in the expression of mitochondrial proteins encoded by the nucleus. We continue the analysis of this phenomenon by evaluating the effect of various mutants on longevity.

 

senescent

Culture of Podospora anserina. Left, location where the ascospore germinated. The mycelium then developed toward the right until growth stopped. Arrest is accompanied by a dark pigmentation of the dying cells (Barre de Sénenescence). Unlike the cells of the Barre de Sénescence, those located near the germination point are alive. The culture took about 3 weeks to proceed.


 
The animation shows the process in a dynamic and accelerated manner.

Senecence

 

We have also identified some PDC genes. They code for proteins involved in cytosolic translation and the PDC mutations trigger an increase in translation accuracy! We are currently investigation this unexpected relationship between translation fidelity and signal transduction.