GEC fait partie du Laboratoire
Interdisciplinaire des Energies de Demain (LIED), UMR 8236
Tel: (33) 1 57 27 84 72
has not yet yielded all its secrets! Especially, the nature of the cytoplasmic
determinant is still unkown. It leads to cell death and is accompanied by a
"destabilisation of the mitochondrial DNA", a symptom that is
also found in many ageing organisms. Numerous genes influence the
Determinant of Senescence, especially those involved in cytosolic protein
synthesis. We postulate that destabilisation of the mitochondrial is
triggered through modifications in the expression of mitochondrial proteins
encoded by the nucleus. We continue the analysis of this phenomenon by evaluating the effect
of various mutants on longevity.
Culture of Podospora anserina.
Left, location where the ascospore germinated. The mycelium then developed toward the right
until growth stopped. Arrest is accompanied by a dark pigmentation of the
dying cells (Barre de Sénenescence). Unlike the cells of the Barre de
Sénescence, those located near the germination point are alive. The
culture took about 3 weeks to proceed.
animation shows the process in a dynamic and accelerated manner.
We have also identified some PDC genes. They code for proteins involved in cytosolic translation
and the PDC mutations trigger an increase in translation accuracy! We are
currently investigation this unexpected relationship between translation
fidelity and signal transduction.